By: Noorashikin Md. Noor, Tom Defoirdt, Norfarrah Alipiah, Murni Karim, Hassan Daud, Natrah Ikhsan
Author: Farah Izana Abdullah
Vibrio campbellii is amongst the most important pathogens in aquaculture. One of the mechanisms that controls the virulence of V. campbellii is quorum sensing; the cellâ€toâ€cell communication using small signal molecules. The signal molecules are known as Harveyi autoinducerâ€1 (HAIâ€1), Autoinducerâ€2 (AIâ€2) and Cholerae autoinducerâ€1(CAIâ€1) which will be detected by membraneâ€bound receptors that feed a shared signal transduction cascade resulting in full virulence. Quorum sensing becomes an interesting target for the development of novel therapies to control disease caused by V. campbellii. Therefore, a study was conducted to investigate the impact of quorum sensing on the virulence of V. campbellii towards tiger grouper larvae. Findings shown that higher mortality of grouper larvae challenged with V. campbellii strains with an active quorumâ€sensing system when compared to larvae challenged with mutants in which the quorumâ€sensing system was inactivated. The signal molecules HAIâ€1 and AIâ€2, but not CAIâ€1, are essential for full virulence to grouper larvae. These data suggest that quorumâ€sensing inhibition could be an effective strategy to control V. campbellii infections in tiger grouper.
Web: DOI: 10.1111/jfd.12946
Date of Input: 27/09/2021 | Updated: 27/09/2021 | m_fakhrulddin