Quorum Sensing Is Required For Full Virulence Of Vibrio Campbellii Towards Tiger Grouper (Epinephelus Fuscoguttacus) Larvae | INTERNATIONAL INSTITUTE OF AQUACULTURE AND AQUATIC SCIENCES
» ARTICLE » Quorum sensing is required for full virulence of Vibrio campbellii towards tiger grouper (Epinephelus fuscoguttacus) larvae

Quorum sensing is required for full virulence of Vibrio campbellii towards tiger grouper (Epinephelus fuscoguttacus) larvae

By: Noorashikin Md. Noor, Tom Defoirdt, Norfarrah Alipiah, Murni Karim, Hassan Daud, Natrah Ikhsan

Author: Farah Izana Abdullah

 

Vibrio campbellii is amongst the most important pathogens in aquaculture. One of the mechanisms that controls the virulence of V. campbellii is quorum sensing; the cell‐to‐cell communication using small signal molecules. The signal molecules are known as Harveyi autoinducer‐1 (HAI‐1), Autoinducer‐2 (AI‐2) and Cholerae autoinducer‐1(CAI‐1) which will be detected by membrane‐bound receptors that feed a shared signal transduction cascade resulting in full virulence. Quorum sensing becomes an interesting target for the development of novel therapies to control disease caused by V. campbellii. Therefore, a study was conducted to investigate the impact of quorum sensing on the virulence of V. campbellii towards tiger grouper larvae. Findings shown that higher mortality of grouper larvae challenged with V. campbellii strains with an active quorum‐sensing system when compared to larvae challenged with mutants in which the quorum‐sensing system was inactivated. The signal molecules HAI‐1 and AI‐2, but not CAI‐1, are essential for full virulence to grouper larvae. These data suggest that quorum‐sensing inhibition could be an effective strategy to control V. campbellii infections in tiger grouper.

Web: DOI: 10.1111/jfd.12946

Date of Input: 27/09/2021 | Updated: 27/09/2021 | m_fakhrulddin

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